Laura, a high school volleyball player, went to visit her family physician because she has been feeling fatigued, unwell, swollen ankles, and despite her workouts – she has gained 5 pounds this week. The doctor asks is she is taking any medications and Laura divulges that she has been taking about 3000mg of ibuprofen per day for a knee injury she suffered during a match one month ago. Tests reveal that Laura’s GFR is 25mL/min.

1.      Based on her tests and symptoms – what condition is Laura now suffering with?

2.     How did the excess ibuprofen cause this condition? Be specific and discuss events at the glomerulus.

3.     Will Laura’s blood pH be acidic or alkaline? Why?